I guess I will ask for what kind of business? Are all of the computers used by the same or similar group of users, e.g: the computers are used in an insurance company only by 500 claims adjusters? Or they are used in a company that has 10,000 employees who encompass a wide variety of job disciplines such as hardware, software, and test engineers, and management, manufacturing, etc. employees?
If the latter, it won't work. You can deploy a standard set of applications to every computer. But not a standardized IE homepage, desktop background, and desktop icon set. Well you can, but the 733t h4x0rs among your group of employees will defeat your efforts.