ccleaner is a good tool to keep handy, in general. The reason it works is it cleans out temp files, which is where oftentimes many different "baddies" will hang out.
You could also try one or both of these general clean-up tools that I've used on occasion, and they both seem to actually work rather well, from my experience:
Glary Utilities
and
Iobit Advanced SystemCare Free
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The next 2 items are really the things I'd suggest installing after you clean your system up in order to prevent reinfection:
A good app to keep installed, and updated ever so often, to help prevent the installation of any malware:
SpywareBlaster - That one doesn't use ANY resources, as it doesn't have to actively run in your system. They do have another related tool which is more of an active scanning program, but I found, at least on a couple machines on which I tested it, that it seemed to use too many resources - for my liking.
And especially if you aren't sharing files between PCs, then this program is EXCELLENT for protection:
Online Armor - it's a firewall with built in "program guard". It's extremely powerful, yet uses very little system resources.
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If you REALLY want to make sure the malware is gone, do this:
[ol][li]Download
DBAN.[/li]
[li]Burn the ISO image to a CD (or use the floppy or USB drive method).[/li]
[li]Back up any important data. {If you backed up your data to an attached hard drive, then once finished, shut your PC off, unplug THAT hard drive, and THEN continue to the next step.[/li]
[li]Boot from the CD you burned.[/li]
[li]Type
[blue]autonuke[/blue] and walk away from the PC - it'll take typically at LEAST an hour or two, and can sometimes take more than a full day - normally, it seems to complete within a couple hours[/li]
[li]Reinstall Windows from scratch[/li]
[li]Be sure Windows is up do date[/li]
[li]Install your security apps - your choice from what you have tried, what's listed here in this thread, etc.[/li]
[li]AFTER all of that, shut down the PC and reconnect the hard drive you used to back-up your data (if it was on an attached hard drive), restart Windows... Or if you just backed up to a Thumb/Flash drive or CD/DVD or something, you can connect/insert that now.[/li]
[li]Before copying your backed up data back to the preferred location(s), I'd suggest scanning all those files with at least 2 scanners to be sure that is clean as well, since it wouldn't be all that difficult for a virus to have copied itself to your "My Documents" or "Favorites" for instance.[/LI]
[li]Once you verify your data is clean, you can copy it back in place.[/li][/ol]
If you have the time to do so, a reinstall is generally the best option once you've been infected. And besides that, you do get performance benefits, usually, as you by default clear out any temp files and/or system changes that could be hindering your system even w/o a virus.
--
"If to err is human, then I must be some kind of human!" -Me