i'm not sure if you can run it IN a powerpoint presentation, but you can run an application from powerpoint. click on an object on your slide, and got to Slide Show->Action settings. If you want to run the program when the user clicks the object, go to the Mouse Click tab. Then choose the Run Program option, and enter/browse for the program you want to run. If you want to run the program when the user moves the mouse over the object, do the same thing under the mouse over tab.
Not sure if this is exactly what you are looking for, but i hope it helps.
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