Ultimately this comes down to what is deprecated in each version and whether or not you use a deprecated feature. Generally Access is very backward compatible even if it is behavior that is broken... It tends to do the same things wrong and little is fixed.
From that POV, I would go with the latest version you do not have a compelling reason not to jump to.
That said I would read the what's new article for each version of Access since 2013 and if it does not mention what is removed, search for that. I personally was not bit in moving to office 365 aside from the fact they keep 'improving' it / moving things around on me. Ususally features are near the old place but I am a creature of habit and easily annoyed by such things. For context I'm still mad about the loss of toolbars with the introduction of the Ribbon. Some may find my view petty.
Thank you for your input. There seems to be little difference between 2019 and 2021 from what I can see. Unless others have a view, I suppose 2021 is worth going for as you would think it would be more debugged??
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