Be careful of the Index Tuning Wizard. I have to disagree to the sentiment that it's a wonderful tool. It may be a quick way to get some performance boost out of some of your queries, but it is a relatively rote tool.
SQL-7's Index Wizard just never seems to draw a line at diminishing returns.
That is to say, it always seems to take the 'easiest' choice for an index. What fields are in the WHERE clause? Ok, let's make an index with 'em all. That's something a trained monkey could do. Not that I expect magic, but when I was working with Oracle, that seemed to optimize with a little more thought, for instance, it would exclude fields where the uniqueness was very low and an index wouldn't really help much. But with MS, "if it's in the WHERE clause, it's in the index" seems to be the mantra. Or with Aggregate (Group By) queries, I've seen it just index all fields referenced!
So the gist is, if you used the index wizard on everything, you end up with an over-indexed database, and this can drastically slow things down if it's a highly transactional system, as well as increase the size and maintenance workload. To really get things tight, you need to analyze your data and look at the fields, know the data, approximate row counts,field uniqueness percentages, etc.
Just my opinion...
--Jim