What you want to do is use the same design structure as the "Find Unmatched Query Wizard", but extend it to the additional fields you want to check for. Look at the design of the query that the wizard gives you. It uses a left join that gives you "ALL records from 'table A' and only those from 'table B' where the joined fields are equal. It also adds a single criteria that says the joined field in 'table B' must be null. Thus you get all records in 'table A' that don't match to 'table B'.
All you have to do to extend this to multiple fields is to add left joins for each additonal field you want to match on. I usually add additional criteria that each additional field in 'table B' must be null as well, but as I'm writing this I don't think this is necessary.
After I got the hang of this I stopped using the wizard altogether because it's faster to set up the query in design view.
Jeff