Does ODBC stop working when you've got SP4 installed? What else is installed on this machine? I've heard of Windows 2000 SP4 causing certain ports to close but haven't been able to confirm that.
Try deleting the registry key:
HKEY_USERS\.DEFAULT\Software\Pervasive Software\Communications Requester\Version 7\Settings\LockSAT
If that doesn't work, you might try disabling the programs one at a time to see if Pervasive starts working.
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