IEEE488 is commonly refered to as GPIB. Many electronic test insruments have GPIB and/or RS232 ports. The RS232 is more straight forward but is not a fast as the IEEE488 and in some cases the instruments full feature set may not be available under RS232.
RS232 can be addressed more directly from your app, wheras GPIB is best handled through a driver and sending calls to that driver that comes with the host GPIB controller.
NI has a great deal of info on the subject. Also try agilent (formerly HP). They invented the original standard (HPIB) which latter became GPIB (General Purpose Interface Bus) then to become standardized to IEEE488 (actually now IEEE488.2) There are app notes on agilent website that deals with programming their test instruments to RS232 and GPIB
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