I have a computer that I use for my FTP server, a game server and my SMTP server. It’s on 24/7/365. Earlier this year I had to replace the fans other than that no problems. My main computer I’m on now is on for days at a time then I’ll get a hair and turn it off each night. So far no problems with it but it’s only six months old. The den computer is off/on constantly and I have recently had to replace the HD (was 3 year old WD), a memory card failed in December and the video card (ATI S3 Virge PCI) flaked out last weekend. So from my home experience, let em run with a break every now and then… Of course the big servers etc run 24/7 but they are designed for it. Set monitors to turn off after say 45 min to and hour. I don’t run screen savers either but I’m a power user and want that last little 2/4% of CPU for whatever. Biggest thing I can think of is constantly blow them out, couple times a month even if you’re in a clean environment. Keep em cool, my main box has six fans with an external power supply. Sounds like an airplane warming up in here with everything on. Heat is an enemy of everything so fans in everything, even my twin KDS XFlats. Dust is electrostaticly drawn to computers; TV’s, monitors etc. run an air cleaner with a negative ionizer. I bought a little 2HP/4 Gallon air compressor from Harbor Freight for $89. Cute little thing and stuck a small drier on it. Sets under my bench here, flip a switch and get a blo… never mind… It won’t run an air tool but will keep computer nice and clean! Peace Long winded SOB aint’ I?