As long as the ATX case is tooled for the MATX mobo...if it is an old case, it may not be tooled for the smaller board...in other words, the MATX board will definately fit inside the ATX case, you just might not have the right screw hole alignment to secure it! If your case has a plethera of holes spaced at places your ATX mobo would never use, chances are the MATX board will fit okay.
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