Yes you can use a M2250 or a CIU, a M2250 has 2 x 25 Pin RS232 connections, one is used to connect the 25 pair which connects to the Meridian, the other can connect to a Smile PC using a 25 to 9 Pin cable. I prefer using a M2250 console with Smile or any other PC Console, as if the PC Crashes/Fails the operator can stil take calls using the M2250 in the 'old fashion manner'.