What software do you run/data do you keep? You could install programs on second drive rather than with o/s (so, uninstall the largest apps and reinstall to for example D:\Program files). And keep all data on second drive too (eg, if it all goes into My Documents, relocate my documents to second drive. XP's tweakui can let you do this - Google to find it).
Or you could buy a new HD of course! (never been cheaper)
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