I can't guarantee it's the same for 2004, but on 2006 it's pretty easy - all you have to do is change the IP range for the adapter,or in the case of 2006, the network entity 'internal'.
ISA seems to see objects rather than details. The external adapter doesn't even have an IP address associated with it. I moved our ISA server from a DSL connection to a router/fibre connection with a completely different IP address, and it worked without any changes at all.
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