this is a difficult malware/spyware,If you boot into safe mode like ifix1 said then do a regedit, click on the edit button and click find, and do a search for the exact name of the spyware(Isearch or Isearch.exe), when you find it delete the string and if it is in a key by itself delete the entire key also then hit F3 or continue searching untill all keys are removed. once you search through the entire registry and delete every key(that has to do with your spyware), do a search on your computer (c drive) for isearch and delete any that match your search, then restart to normal mode, all spyware should be gone.... this works with any spyware file jsut change the name. for the ones that ad-aware and spy-bot won't pick-up Hope that Helps! -Joe