I have completely re-written tha access list, all of them.
Back up your config and remove ALL access lists and start with the following.
IF you do have an internal ISA server make sure that any traffic going through it to the DMZ is not natted otherwise it will not work, have seen this before.
object-group icmp-type ping
icmp-object echo-reply
icmp-object time-exceeded
icmp-object source-quench
icmp-object unreachable
object-group service smtp tcp
port-object eq smtp
object-group service pop3 tcp
port-object eq pop3
object-group service
port-object eq www
object-group network smtp-server-outside
description smtp outside static to internal
network-object host 62.49.103.146
object-group network smtp-server-inside
description smtp from inside server to outside
network-object host 192.168.xxx.xxx
object-group network outside-interface
network-object host xxx.xxx.xxx.25 255.255.255.248
object-group network all-subnets
network-object 0.0.0.0 0.0.0.0
object-group service domain tcp-udp
port-object eq domain
object-group network all-subnets
network-object 0.0.0.0 0.0.0.0
object-group network dmz-www
descritpion
from inside
network-object host 30.30.30.201
network-object host 30.30.30.202
object-group network
description
to outside statics
network-object host xxx.xxx.xxx.26
network-object host xxx.xxx.xxx.27
object-group network local-lan
network-object 192.168.0.0 255.255.255.0
object-group network vpn-client
network-object 192.168.0.0 255.255.255.128
object-group network no-nat
descrition all target networks we do not nat to
group-object vpn-client
group-object dmz-www
access-list inside permit tcp object-group local-lan object-group all-subnets object-group domain
access-list inside permit udp object-group local-lan object-group all-subnets object-group domain
access-list remark the above allows domain lookup from anything inside to anything outside
access-list inside permit tcp object-group local-lan object-group all-subnets object-group www
access-list inside permit tcp object-group local-lan object-group dmz-
www
access-list inside permit tcp object-group smtp-server-inside object-group all-subnets object-group smtp
access-list inside remark the above permits outgoing smtp to all addresses externally
access-list inside permit tcp object-group local-lan object-group all-subnets object-group pop3
access-list inside remark the above permits outgoing pop3 to all addresses externally
access-list outside permit icmp object-group all-subnets object-group outside-interface object-group ping
access-list outside permit tcp object-group all-subnets object-group
object-group www
access-list outside remark allows all outside to
the dmz servers
access-list outside remark the above permits packets from everything outside to
IPs
access-list outside permit tcp object-group all-subnets object-group smtp-server-outside object-group smtp
access-list outside remark the above permits incoming smtp to the outside static to mail server
access-list dmz extended permit tcp object-group dmz-
all-subnets
access-list dmz remark allow anything from the dmz servers to anything outside
access-list split-list permit ip object-group local-lan object-group vpn-client
access-list nonat permit ip object-group local-lan object-group no-nat
access-list nonat remark do not nat any traffic from the local lan to anything in the no-nat object-group
nat (inside) 0 access-list nonat
access-group inside in interface inside
access-group outside in interface outside
access-group dmz in interface dmz
Let me know how it goes, I am away tonight, back on line late tomorrow.