You'll get a ton of answers, as everybody likes different products. Here at work we use (and I recommend) Sybari's Antigen product for e-mail antivirus. They also have anti-spam products. See
Spam, is it's best solution, runs about $1/user and requires minimal maintenance (runs on their servers)... they do have AV software, but it is on their server. This would not protect your internal mail.
I have used Trend and Norton (both of the latest versions) and prefer Trend as an AV solution. They do have a spam filter, but I do not think highly of it.
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