Seems to be a VB error, means file/path can't be found. Suggest you check the program directories for Delta/CCC installed to make sure all applications/DLL's are in correct place. If it comes up constantly I guess it must be a running service trying to access something that has moved. You may have to re-install software to correct the problem. Or service trying to restart, missing db/log file for an application.
I would suggest stopping services in a controlled manner to find out which one it is. Check event log to see if it has any more info in either application or system.
Or Reboot
Or possible FAT table corruption
Or possible spyware/Virus, have you checked this yet?
Or do a software update, not seen this myself ever, but you never know.
Or Re-install applications/System as last resort