I doubt that it does. I reccomend runing 20Clicln.bat with the /scrub switch to remove the client before replicating the image. Use a logon script or network discover / installation to deploy the clients after the machine has been deployed.
Sysprep does not affect the SMS GUID. You need to remove the SMS Client from the machine to be imaged prior to running Sysprep on it. Sysprep takes care of clearing up the SID problems in the registry and such.
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