Protection is one thing, but prevention is another. Sketchy web sites, free downloads, adult content, opening strange emails or following links in emails - these are the paths of infection. But, if you want to visit more than your bank's web site and read email from more than a few people, I guess you have to live with some risk.
That is a particularly bad piece of malware with no real way to unencrypt without paying. It's the next level of ransomware where the hostage (your data) is often killed. OFFLINE backup is your friend here. I see that it can infect external hard drives as well and so ONLINE backup (not online meaning the web) is not helpful.
I would probably use any of the free anti-virus products along with the paid version of MBAM to protect someone that was very important. But the a-v must be set up to ignore the MBAM processes running or there will be a conflict.
"Living tomorrow is everyone's sorrow.
Modern man's daydreams have turned into nightmares.