Cat5 Split pairs mean that the Wiremap is incorrect when you made up the cables. A good Wiremap is: 1-2, 3-6, 5-4, 7-8 at both ends(wirecode T568B states: 1-Orange/White, 2-Orange, 3-Green/White, 4-Blue, 5-Blue/White, 6-Green, 7-Brown/White, 8-Brown). If you follow this scheme with all of your cables, you will no longer have split pairs.
Split Pairs generate a tremendous amount of noise on the cable, but does not necessarily mean it will not work. Short links usually work with split pairs because ACR (Signal to Noise Ratio) checks out, however, as the length increases, so does Attenuation (signal loss) and the noise may be too much for the signal to be interperated at the far end.
Full Duplex is simply the ability to transmit(TX) and recieve(RX) on the same pair. In 10\100Mbps Full Duplex, this means a NIC can TX & RX on both pairs (1-2 & 3-6).
Only Gigabit ethernet (1000Mbps and beyond) uses all four pairs in a Full Duplex scenario.
So I would say that having split pairs on 5-4 & 7-8 in a 100Mpbs Full Duplex scenario would probably work (although NOT recommended) because there is no signal actually being transmitted on those wire-pairs.
There may be some switches out there that may utilize a third pair (eg: for auto link negotiation perhaps) but not for standard 100BASE-TX IEEE 802.3 ethernet traffic.
"In IT, 'Proprietary' is just a buzz word meaning: it's not a standard...yet"
RON GROULX