I think any of the above are okay. Here's what I usually tell people who ask:
Avira Antivir offers the best protection, period (though none are perfect).
Microsoft Security Essentials offers some of the best, but I don't think as good as Avira, protection. However, MSE is also the easiest to use of any AV product I've ever seen. You practically will not know it's there unless it finds a problem, or occasionally it may tell you that you need to let it run a scan or update, if it didn't happen automatically for some strange reason.
AVG and Avast! are okay, but like others, I started noticing too much resource usage from AVG of late, and it didn't seem to catch as many baddies as Avira or even MSE.
Avast, from the little bit of time I've tried it (been at least 2 or 3 years ago, if I remember correctly), focuses too much on more of a kiddie-type look, I guess you could call it, rather than protecting your system. Still, not BAD, just not as good as the other 3, in my opinion..
So, if I rated them from #1 to #4, it'd be:
1. Avira Antivir
2. Microsoft Security Essentials (I'd move it to #1 for someone who is clueless about computers)
3. AVG
4. Avast!
But really, I suppose any of those will do pretty well enough. And if you throw in these for protection:
1. Firewall - Comodo Internet Security (#1) or Online Armor for 32 bit systems
2. Malwarebytes Antimalware for scanning
3. SpywareBlaster for protection - innoculation
4. SuperAntiSpyware for some protection and scanning
Run as a "limited" user, or "user level" account in Windows if you can make yourself do it, then just use an admin-level account (password protected) when necessary for installing/uninstalling. I've done this on a couple of computers at home with no issues, but I've not forced myself to do it on the other 2 systems running Windows - yet. The time will come, though, the time will come.
Make sure whatever browser you are running is up to date, and make sure Windows is up to date. If you use MS Office, then make sure it stays up to date, at least for security updates. And for any other application you use a lot... for instance, Flash and Adobe Reader - I'd make those top priorities for keeping up to date as well. Java is yet another. Basically anything that could open your system to threats from the WWW.
Also, if you don't already have a router, then get one. If you don't use some sort of router-based firewall, then eventually all the software fixes will let something through. If you use a router, than much of the threats will be held at bay before even seeing your machine(s). Of course, if you have more than one computer connected to the Internet, more than likely you have a router already.
Now that I've semi - gone off into the weeds, I'll say ado.
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