That is a bit complicated because Outlook saves the signature file to the local hard disk and this signature is specific to the Outlook Profile that is in use. In this case it will be a bit hard to share it within the GAL. However, if you are looking at applying a standard message to all messages, it is easier done through the IMSext.dll which is confgiured through the Registry of the Exchange Server. Let me know if you need more info on this.
Kuria
Depending on how uniformly structured your setup is, you could make a logon script that changes the appropriate registry key depending on the OS of each client. You'd just have to do some digging to find the correct key location for each OS. I know that in Win2K the key that defines the signature is located somewhere like:
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