Is this a corporate environment? Could be some tech's might be having a bit a fun with you and have installed a backdoor trojan. This happened to my buddy at work from the software team. He wasn't happy but I was quite amused, watching him try to wrestle control of his own mouse was hilarious.
Sounds like a virus but if it comes out clean this is really weird unless you have scheduled tasks running in the control panel which would place a shortcut by your clock. Is it just certain times or random?
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