So, while the Salesforce Click-to-Dial CTI Adaptor has never been great in universally Supporting all browsers, the latest SP4 (and SP3 Adaptor on an SP4 1xP) is not working for me across all of them on 9.1 sp4. It loads the 'keep open page, it loads the softphone into the the Salesforce Page and then you are stuck where it either clears credentials when trying to authenticate you to the 1xP (One X Portal) or it simply does not respond........any clues (yes Pop-Up Blocking is Off and the Shield has been clicked to allow insecure content so the that unsecure adaptor can work on the secured Salesforce Page, - results are the same in IE/FF/Chrome))