Have you tried changing the pointer back to windows default in control panel > mouse > pointers tab. Select windows default scheme.
If that doesn't work post back.
A number of things can cause this - atleast now that you can boot into safe mode you can atleast start determining what it could be and should be able to fix it or atleast backup you data.
Does anything in device manager have a yellow exclamation mark next to it? If yes post back more info...
In gpedit.msc go to the following:
To get back Task Manager:
User Configuration > Administrative Templates > System > Ctrl-Alt_Del Options > Remove Task Manager - Set it to Disabled.
To get back Command Prompt
User Configuration > Administrative Templates > System > Prevent Access to the...
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