I have had pretty good luck with the latest versions of DisKeeper. You are able to customize the jobs on many levels in order to aleviate any performance issues on the DB while it is active.
A properly setup disk drive for a SQL Database shouldn't have any fragmentation on it. After you defrag the drive you'll want to remove what ever files are causing the fragmentation on the disk.
Denny
MCSA (2003) / MCDBA (SQL 2000)
MCTS (SQL 2005 / Microsoft Windows SharePoint Services 3.0: Configuration / Microsoft Office SharePoint Server 2007: Configuration)
MCITP Database Administrator (SQL 2005) / Database Developer (SQL 2005)
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