I personally have not, but some people that I know in a different company were using one, they had nothing but good things to say about it. They did end up replacing it with a Cisco CSS so that they could be an all Cisco shop. I have been looking into getting on myself, currently we use Citrix and we mainly just publish desktops any more so we are looking to go with straight Windows TS. One thing about an F5 is that it is expensive, no as bad as what we pay for Citrix licensing, but they don't give 'em away. We may end up with a Barracuda Load Balancer. They are an entry level appliance, fairly inexpensive, but I have had some issues with their support contracts recently and I am a little "gun shy" of buying anything from them for awhile.
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