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Once all of the apps, drivers and plug-ins move to 64-bits, there will be no need for 32-bit backwards compatibility
Photoshop, Excel, and FireFox already have 64 bit versions.
x64-only: This isn't a hard prediction to make. Before Windows 7 even launched, Microsoft said that its successor, Windows 8, would be the very last version of Windows to support the old 32-bit architecture. This makes sense. There hasn't been a 32-bit x86 processor (not including Atom) on the mainstream market for several years.
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Prior to the release of Windows 7, Halsey writes, Microsoft warned software developers that they had just six years left to make sure all of their software, plug-ins and Windows extensions were 64-bit. That's perfect with a 2015 timeline. So don't say you weren't warned.
No More Legacy Support: This would be dependent on moving to 64-bits. That would mean no more of the WoW64 architecture to support 32-bit windows. Once all of the apps, drivers and plug-ins move to 64-bits, there will be no need for 32-bit backwards compatibility. If you do need Windows XP support for some reason, it will likely be through sandboxed virtualization similar to what is done in Windows Server 2008, which is 64-bit only.
Olaf said:It would be nice to see an official statement of MS about this, or at least a reference to the alledged MS warning about the end of 32bit.