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if not intersect(target, activesheet.cells(1,"J").entirecolumn) is nothing then
macro1
elseif not intersect(target, activesheet..cells(1,"B").entirecolumn) is nothing then
macro2
end if
If target.column = 10 then
'your code for changes in column J
elseif target.column = 2 then
'your code for changes in column B
else
'don't run code
end if