Threshold for the most part you can leave at the lowest level to get the most (think of everything about unsharp as backwards since it really sharpens) - and the radius is obviously how far you want it to go. Generally I try to go for about 70%, threshold 0, and radius at .7 - no overkill, but some defining.
It's really playing around and previewing what you like. So much depends on the quality of what you're starting with.