Save for Web gives you more options, and creates a smaller file by omitting file information that is not needed. For example, you can:
1: Preview the results of different compression settings
2: Apply different compression settings to various parts of the image
3: Change the image size
4: Try different file formats
5: Specify a file size in Kb that you need it reduced to
6: Add blur to reduce JPEG artifacts
7: Save settings for reuse in other images
8: Automatically converts the image to RGB
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