Ok it depends what you are doing here.
It seems you have 2 tables and want 3 functions available.
tbles
Protocol
Pathology
Protocol has ID linked to Pathology ID (but some Protocol ID's have no matching Pathology ID's i.e. no pathology records.)
I suggest you setup 2 forms, 1 for adding a new record to Protocol & thereby Pathology if necessary. This form might best be split into a main form (source Protocol) and subform (source Pathology). then put the fields to be added in the Proctocol (main form) and then the ID of the subform can equal that of the Protocol. If I am correct in believing a protocol record can be entered with without a pathology record you will need to have a user defined function such as a button to define if the pathology ID should be updated and the rest of the pathology record be made available.
You will also need another form to update and delete the records. You can update by simply overwriting records where the controls are linked to the tables and again using the main/Subform will allow tis. However, you cannot delete the record by blanking out the record on the form, you will instead have to perform a task, probably building a delete query will be the best option here, and a button to invoke it.
After you have all that sorted you will need to look at validation - is the user updating with the correct information, have they left something blank when they should not, are they adding a record that already exists etc etc.
I hope I understood your questions correctly.
NB you will also need to look at the type of join you have in your queries as I imagine you will want to view all records in Protocol and those that match in Pathology where as the standard join will only allow you to see records that have the same ID in both tables thereby excluding the Protocol ID's without a Pathology ID.