The laptops are unuseable when the backup runs, or when Remote Agent is installed? We always run our backups at night so as to cause as little interference as possible. There are times however when a backup gets delayed to the point of running during the day. Certain computers will slow down, and we even used to have a website that would start yielding errors when the backup ran during the day.
If Remote Agent itself makes the laptops unuseable, you can run the backups without it, it'll just go a lot slower.
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