We are running Domino 6.5.3 and when a user selects their Out-of-Office message to "enable" it does not send out the message saying the user is out of office when an email arrives.
Have you checked whether the agent remains activated after the user has enabled it? We are using database quota and we experienced that when the user has exceeded the quota the OOO-Agent didn't work properly.
Another idea: Is perhaps a Design task running that deactivates the agent again overnight?
Next idea: Has the user enough rights on his/her database so he can activate the agent? Under Notes 5 you needed Designer access - Notes 6 Editor should work, but I haven't tested it (We left the Designer access for our users as they had it for years anyway and we didn't experience any problems).
Perhaps it helps...
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