Don't know about ODBC, but if you are going to use Perl to interface with it, you can use DBD::Sybase module with freeTDS libraries. MSSQL started out as Sybase 4.2, so there are a lot of similarities. This means that, with a few limitations, you can interface with MSSQL using open libraries available for Sybase (freeTDS being one of them). If this appeals to you, you can read about it here. I have used this module to interface with MSSQL before
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