First, instead of JPG files, use bitmaps or PCT files. JPEGS have lost data. If you can, go back to your origianl source and save as BMP or PCT.
Watch your pan and zoom speeds -- too much can make a viewer queasy.
If you're recording voiceovers, do those in a good recording location -- it might be worth it to practice for a while at home, then rent a studio and do it right.
Lay down the voice audio first, then the still images, then apply effects to the images (hint: filters>>imagepan in Premiere), then lay down any sound effects or music last.
Practice on a few seconds.
If you move too quickly through a high-contrast image, you'll get some motion twitter. There are different ways to knock that down. The one that worked best for me was to simply rein in my tendency to move stuff so quickly. Another technique was applying a directional blur. I suppose you could try adding deflicker, but that's never worked for my images. Might work fine for yours (mine were B&W line art with heavy black and heavy white areas).
I just finished a huge project like this. On my last one, Joe Bob Briggs (if you're into B movies, you'll know who he is) wrote "Ah, this is what it would be like if Ken Burns did horror". Heh.
Good luck! Post URLs of your work here!
Cheers,
![[monkey] [monkey] [monkey]](/data/assets/smilies/monkey.gif)
Edward
"Cut a hole in the door. Hang a flap. Criminy, why didn't I think of this earlier?!" -- inventor of the cat door