In your own programs, you can use MySQL's own libmysql, (functions like mysql_connect, mysql_query etc.).
The reason you must use ODBC for connecting from external applications (such as Access, Excel or Outlook) is that ODBC is a standard interface meant to support a lot of different databases. An "ODBC Driver" is simply a module that handles standard ODBC function calls and turns them into database-specific calls. Although it is slower it still supports a wide range of databases through one uniform interface.
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