I would agree with Bill here, done a lot of 24x7 site backups this way (no DB), about the only errors I have encountered with mksysb reporting failure is when some dynamic files (e.g. incoming email) were downloaded to the system and were recorded in the backup image file during initial mksysb startup. Obviously by the time the mksysb got to backing these up according to the list they were long gone (processed), so a "failed" report in smitty didn't bother me much.
What I did was to turn detailed reporting on in the mksysb, so I could scroll through afterwards and see if this was the case, or perhaps something more critical caused it to fail.
IBM Certified Specialist - MQSeries