We use Compaq and IBM DDS4 drives. 1 has been running over 3 years now, 1 over 2 years, and 1 for just over a year.
In two of our DDS4 drives we use nothing but DDS3 tapes. In the third one we use a DDS4 tape only on a Friday night (for a normal backup). We run NTbackup on all three servers and have never had any problem restoring any tape (DDS3 or DDS4) from any DDS drive.
I don't know if this makes any difference but we use only Sony DDS tapes. We've found them to be the most reliable.
Cheers.