Re. the speeds. LTO4's require the data to come off the servers pretty quick, and I suspect that there will be times when this just ain't going to happen.
One little trick, I'm sure you be aware of ...
Also, possibly dependant on the backup software ...
Try multiplexing several machines to one tape, trail and error, but try say 4, this way, hopefully the data flow will be quick enough from all 4 so that at some point, at least one of them is "ready to write", so if one has a slow moment, one of the others will take it's place.
Martin