As long as the printers approach it as a duotone, then you should be fine. The really great thing about the format is you are not limited to two colors (alsways assuming your press can do more, that is).
For instance, one use of the format I saw was a christmas scene wherethere was a victorian street and the two colors were PMS295 and PMSRed 032. What the client did is to make the bows almost all red and then used the blue and red to create the rest of the scene.
When you look at the channels, there was the scene repeated twice except that in the red channel, the bows were very dark while the rest of the scene was a light, ghostly grey. On the blue channel it was the opposite. Very simple use but very effective.
Now if the client wanted something more colorful, a green like PMS3145 could have been used to do the garlands and the pine trees and that plate would have almost no image to it except for where the green was and the other two plates would, of course have the bits missing where the green would go.
The trick to doing this is to use the eraser like a paint brush with the Opacity set to something like 10% and using a soft sided brush. Zoom in on the area you want a color to be prominent and select the correct other channel (in this case say were doing the bows from the above example so select the blue channel) and carefully erase the area of where the bows should be. If you have both channels showing, you'll see the effect right away.
Now if you want the predominant color to be blue, then select inside the erased areas, invers and use brightness and contrast to lighten the whole and you should have a pretty good peice.
Granted for a really good peice, it will take some time to tweak all the little areas you want to have it work out but with practice you can do these things cold.
I use them mainly for things like scanning in hand written stuff that has to go on top of scanned line art so that it looks like the person wrote all the stuff right in but in reality it's a multichannel with black and reflex blue.