Like luciddream said, you should be able to use any database that has a ODBC or (preferably) an ADO driver.
If you're building a website that needs 99.99% (four-nines) or higher availability, you need either Oracle 8i or MSSQL2000 running on clustered hardware (DB2 is supposed to be good too, but I don't have any experience with it). If you only need three-nines availability (99.9% uptime), you can skip the clustering requirement as long as you've got your disk drives in a RAID-5 array.
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