zoomcasper;
This can be a couple of things ranging from easy fo fix to complicated and inexpensive to mildly expensive. Check the easy things first:
1. Open the case and observing ESD procedures (investing a couple of dollars in an anti-static wrist strap is a good idea) make sure all of the cables to the disc drive are in place and secure. Make sure the other end of the data cable is securely in place on the MB.
2. Have you recently tried to uninstall any third-party backup, tape drive or media burning software? Improper uninstalls can leave behind corrupted drivers that have been known to cause this issue. You said that you couldn't get into safe mode. Do you get to the point where you can press F8? If so, don't select Safe Mode from the menu; select "Last Known Good Configuration". This could put things back in working order.
3. If you have a second computer, pull the hard drive from your system and put it in the second system as a slave drive and see if you can access the drive. This will show whether or not the drive is any good and if so, give you an opportunity to run a complete virus scan and off-load data.
4. If the drive is OK, put it back and use your original installation CD. (You don't say what your OS is, but for the purposes of this, I'm assuming it's 2K or XP). NOTE: This will NOT work if your CD is a vendor system restore disc! Boot from your CD and,
now read this carefully, select INSTALL, NOT REPAIR!!!! When the CD finishes loading files into memory, it will detect any existing OS installs on the HDD and ask if you want it to try and repair the OS. Select Yes. This will overwrite the system files and drivers while leaving your installed applications and data intact. You will, however, lose any service packs installed since the original loading, so you will need to reinstall them.
5. If the drive works in another system but not when you put it back in your system and try Step 4, your PSU may be failing. If the drive isn't recieving enough power to spin up fully, you could see this type of error. If the PSU is more than a few years old or if you recently got hit with a power spike, it might be toast. SIDE NOTE: If you pick up a new PSU, buy a UPS at the same time. They aren't that expensive and provide a lot of protection from dirty power and such.
6. If all of the above gets you nowhere, you may need a new HDD.
Let us know how it works out....
Mike, The IT Guy.
Life is too short to drink warm beer....