You could, read the file, and put the contents into an array, and then ut it into he DB.
What format does the table have? fields, types etc...
How re the URL's separated in the txt file? by a comma, a space etc...
If this is a one time thing, then maybe the import feature in phpmyadmin is the way to go. if it is something that is going to happen frequently, then maybe a webpage with the approprite code is the way to go.
Tell us what exactly it is you want and we can help further.
----------------------------------
Ignorance is not necessarily Bliss, case in point:
Unknown has caused an Unknown Error on Unknown and must be shutdown to prevent damage to Unknown.