Not possible unless you take some precautions.
First, I would suggest turning off the "mark read when previewed". This option generates a RR without the need to open the doc.
Second, I would suggest you replicate your mail to your local machine. When you receive any suspect mail (virus or spam or unknown), the replicate your mail and change your location to LOCAL.
This will have for effect to cut your Notes client from the network, effectively severing the possibility to send mail.
When in LOCAL, all mail you send will be stored in a special database called "Outgoing Mail".
You can then open your mail, trash the spam and review suspicious attachments.
ATTENTION : this is NOT a protection against virii. Open an infected attachment and your machine WILL get infected.
But having no link to the server will limit the disaster.
Once you have dealt with all suspicious mails, you can open the Outgoing Mail db and delete any message you do not specifically remember having sent.
Then, switch back to Office and resume normal work.