What makes you think it's open? It shouldn't be open unless you're running an FTP server. Even if you have an FTP server running causing the port to be open, any firewall (including the one built into XP) can block incoming connections on port 21.
Dreamweaver should be uploading to port 21 on the FTP server, not on your machine. If you want to check, open a command prompt. Then while uploading with dreamweaver, at the command prompt type netstat -a.
Ports 21 & 80 are FTP server & web server respectively. Do you intend for either of these to be running? If not turn them off. If yes, then those ports need to be open for those services to work. Keep in mind that file sharing apps like Kazaa act as a web server.
Let's get to the heart of the problem...are you running an FTP server and a web server on your machine?
If you have a router, you block ports at the router (some older routers left port 21 open for ISP maintenence - but they used strong passwords for the FTP transfer).
What is your physical configuration ADSL, cable, dial-up, modem type, router type, etc?
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