Thenks for the feedback.
We are looking at both options, fully maintained and CoLo. One of the drivers for this project is the cost of equipment, particularly the ongoing cost of upgrading or buying new equipment to replace older boxes. Some vendors allow both options, so this gives us a little more flexibility, although for us to go down the CoLo path, it would only really provide us with greater security, redundancy (power & comms), and monitoring. The cost of the equipment still lies with us, so this may not be the right starting point. As you pointed out mrdenny, to start with one solution doesn't mean you cannot change when it makes more sense.
jimbojimbo, the points you raise are all relevant and have given me additional questions to ask when meeting with vendors. I am particularly concerned about the security of our data, not that we are a high target for industrial espionage, but you can never be too sure. We are in Australia so I'm not sure of the impact on statutory requirements, but I don't think this will be an issue.
I think we have a small to medium sized network (14 servers, some virtualization, mixed 2000/2003 domain, hoping to upgrade to complete 2003 domain, 100+ users). My main concern is that we use a design package that is not only resourse intensive on the workstation, but the files produced are 5-4Mb in size, and we produce 5000 per year.
I feel we are heading towards a part solution which will give me greater redundancy and a better DR solution for our business/financial applications and data, but will still need to maintain some servers locally for the design software.
It's all very complex, but if we put the right effort in, we should be better off.