Yes. There are 2 events for object Workbook you need : BeforeSave and BeforeClose.
Write for VBA object ThisWorkbook 2 subs:
Private Sub Workbook_BeforeClose(Cancel As Boolean)
Application.DisplayAlerts = False
'This will disable alert for saving file
'and will use default answer yes
Dim rng As Range
Set rng = Worksheets("todel"

.Range("A1:A3"

'set range you want to clear
rng.Clear
Application.DisplayAlerts = True
'to give Excel possibility to display other alerts
End Sub
Private Sub Workbook_BeforeSave(ByVal SaveAsUI As Boolean, Cancel As Boolean)
Application.DisplayAlerts = False
Dim rng As Range
Set rng = Worksheets("todel"

.Range("A1:A3"

rng.Clear
Application.DisplayAlerts = True
End Sub
I would suggest to protect you VBA project with password, so noone will be able to delete this feature without password.