Not quite sure what your question is. Can you be more specific? My best guess here is that you want to know if somebody renames your application (ie proggy.exe) to something else, and renames another application to proggy.exe. And you want to be able to detect this.
If that's the case then - no, not without having another program running all the time that is on the look out for this. If this is what you're after, then post back and we'll help you out.