Use the IIF (Inline IF) function. Alternatively, always remember that you can use any function in a query and pass it fields and do any logic you want.
In the Field row, just put:
MyAliasColumnName: SomeFunction([somefield1],[somefield2],[somefieldn])
The function obviously must have the correct number & type of arguments.
The IIF goes like:
IIF(Some Expression,value if true,value if false)
--Jim